Trevor Lawrence finally suffered an injury he can't play through, with the Jaguars officially ruling him out for Week 17.
Keenan Allen and Mike Williams both expect to play this week, while the Chiefs are hurting at wide receiver and the Saints and Bills appear thin on defense.
Kyler Murray is one of four starting quarterbacks listed as questionable, while Jonathan Taylor, Aaron Jones, Elijah Mitchell and Kyren Williams all got the green light Friday.
Bengals linebacker Germaine Pratt may handle an increased workload moving forward with Akeem Davis-Gaither on IR.
Erik Siegrist previews the Monday night matchup with game predictions, fantasy projections and DFS picks as the Rams look to beat the 49ers on their home turf.